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Mutation-Specific Differences in the Relationship between Obesity and Clonal Hematopoiesis, with a Focus on JAK2<SUP>V617F</SUP> and MPN Prevention

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Rolles, Benjamin Sekar, Aswin Serrano-Ron, Laura Faiz, Noorul Mifra Ameerul Perry, Andrea Hillerbrandt, Addison Clare Hem, Jessica Jutzi, Jonas Marneth, Anna E. Niroula, Abhishek Bick, Alexander G. Gibson, Christopher J. Griffin, Gabriel K. Uddin, Md Mesbah Natarajan, Pradeep Ebert, Benjamin Levine van Galen, Peter Al-Shahrour, Fatima Hormoz, Sahand Mullally, Ann

Harvard Med Sch Brigham & Womens Hosp Div Hematol Dept Med Boston MA USADana Farber Canc Inst Dept Med Oncol Boston MA USASpanish Natl Canc Res Ctr CNIO Bioinformat Unit Madrid SpainHarvard Med Sch Brigham & Womens Hosp Div Hematol Dept Med Boston MA USADana Farber Canc Inst Dept Data Sci Boston MA USABroad Inst MIT & Harvard Cambridge EnglandRadboud Univ Nijmegen Med Ctr Dept Lab Med Med Ctr Nijmegen NetherlandsUniv Gothenburg Inst Biomed Dept Med Biochem & Cell Biol Gothenburg SwedenUniv Gothenburg SciLifeLab Gothenburg SwedenVanderbilt Univ Med Ctr Dept Med Div Genet Med Nashville TN USADana Farber Canc Inst Dept Pathol Boston MA USAHarvard Med Sch Ctr Genom Med Boston MA 02114 USAMassachusetts Gen Hosp Ctr Genom Med Boston MA USAHarvard Med Sch Boston MA USADana Farber Canc Inst Howard Hughes Med Inst Boston MA USAHarvard Med Sch Dept Syst Biol Boston MA USAStanford Univ Sch Med Div Gastroenterol Dept Med Stanford CA 94305 USAVA Palo Alto Hlth Care Syst Hematol Div Palo Alto CA USA

Progression of Myelodysplastic Syndromes in the MDS Natural History Study (MDS NHS)

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Dezern, Amy E. Otterstatter, Michael Gillis, Nancy Abel, Gregory A. Al Baghdadi, Tareq Bejar, Rafael Deeg, H. Joachim Foran, James M. Komrokji, Rami S. Lindsley, R. Coleman Liu, Jane Jijun Moscinski, Lynn C. Saber, Wael Zhang, Ling Borchert, Christine Padron, Eric Sherman, Seth Difronzo, Nancy Walter, Matthew J. Sekeres, Mikkael A.

Sidney Kimmel Comprehens Canc Ctr Johns Hopkins Baltimore MD USAEmmes Co LLC Rockville MD USAMoftt Canc Ctr & Res Inst Dept Canc Epidemiol Tampa FL USADana Farber Canc Inst Dept Med Oncol Boston MA USAIHA Hematol Oncol Consultants Ypsilanti MI USAUniv Calif San Diego La Jolla CA USAFred Hutchinson Canc Res Ctr Seattle WA USAMayo Clin Div Hematol & Med Oncol Jacksonville FL USAH Lee Moftt Canc Ctr & Res Inst Dept Malignant Hematol Tampa FL USAIllinois CancerCare Peoria IL USAH Lee Moftt Canc Ctr & Res Inst Dept Pathol Tampa FL USAMed Coll Wisconsin Ctr Int Blood & Marrow Transplant Res Milwaukee WI USAH Lee Moftt Canc & Res Inst Dept Pathol & Lab Med Tampa FL USANatl Heart Lung & Blood Inst Div Blood Dis & Resources Bethesda MD USAWashington Univ St Louis St Louis MO USAUniv Miami Sylvester Comprehens Canc Ctr Miller Sch Med Miami FL USA

Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database

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Rolles, Benjamin Bewersdorf, Jan Philipp Kewan, Tariq Blaha, Ondrej Stempel, Jessica M. Lanino, Luca Ali, Najla H. Al Dezern, Amy E. Sekeres, Mikkael A. Uy, Geoffrey L. Carraway, Hetty E. Desai, Pinkal Griffiths, Elizabeth A. Stein, Eytan M. Brunner, Andrew M. Mcmahon, Christine M. Shallis, Rory M. Zeidner, Joshua F. Savona, Michael R. Frumm, Stacey M. Barua, Shougat Chandhok, Namrata S. Logothetis, Constantine Bidikian, Aram Getz, Ted M. Roboz, Gail J. Wang, Eunice S. Harris, Amyah C. Amaya, Maria L. Hawkins, Hayley Ball, Somedeb Grenet, Justin Xie, Zhuoer Madanat, Yazan F. Abaza, Yasmin Badar, Talha Haferlach, Torsten Maciejewski, Jaroslaw Sallman, David Enjeti, Anoop K. Al-Rabi, Kamal Halahleh, Khalid Hiwase, Devendra Diez-Campelo, Maria Valcarcel, David Haferlach, Claudia Pleyer, Lisa Kotsianidis, Loannis Pappa, Vassiliki Santini, Valeria Consagra, Angela Al-Kali, Aref Ogawa, Seishi Nannya, Yasuhito Porta, Matteo Giovanni Della Komrokji, Rami S. Zeidan, Amer M. Stahl, Maximilian

Harvard Med Sch Brigham & Womens Hosp Div Hematol Dept Med Boston MA USADana Farber Canc Inst Dept Med Oncol Boston MA USAYale Univ Dept Internal Med Sect Hematol New Haven CT USAMem Sloan Kettering Canc Ctr Dept Med Leukemia Serv New York NY USAYale Sch Med Dept Internal Med Sect Hematol New Haven CT 06510 USAYale Univ Yale Ctr Analyt Sci Sch Publ Hlth New Haven CT USAIRCCS Human Res Hosp Rozzano ItalyH Lee Mofitt Canc Ctr Dept Malignant Hematol Tampa FL USAJohns Hopkins Univ Sidney Kimmel Comprehens Canc Ctr Baltimore MD USAUniv Miami Miller Sch Med Sylvester Comprehens Canc Ctr Miami FL 33136 USAWashington Univ Sch Med St Louis MI USACleveland Clin Taussig Canc Inst Dept Hematol & Med Oncol Leukemia Program Cleveland OH USAWeill Cornell Med New York NY USARoswell Pk Comprehens Canc Ctr Buffalo NY USAMem Sloan Kettering Canc Ctr Dept Med Leukemia Serv New York NY USAHarvard Med Sch Massachusetts Gen Hosp Div Hematol Oncol Boston MA 02115 USAUniv Colorado Dept Dermatol Aurora South AfricaUniv N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC USAVanderbilt Univ Med Ctr Vanderbilt Ingram Canc Ctr Nashville TN USAHarvard Med Sch Brigham & Womens Hosp Div Hematol Dept Med Boston MA USADana Farber Canc Inst Dept Med Oncol Boston MA USAWeill Cornell Med Div Hematol & Oncol Dept Med New York NY USARoswell Pk Comprehens Canc Ctr Buffalo NY USAVanderbilt Univ Med Ctr Vanderbilt Ingram Canc Ctr Nashville TN USAH Lee Mofitt Canc Ctr Dept Malignant Hematol Tampa FL USAUT Southwestern Med Ctr Harold C Simmons Comprehens Canc Ctr Dallas TX USANorthwestern Univ Chicago IL USAMayo Clin Div Hematol & Oncol Jacksonville FL USAMLL Munich Leukemia Lab Munich GermanyCleveland Clin Taussig Canc Inst Dept Hematol & Med Oncol Leukemia Program Cleveland OH USAH Lee Moffitt Canc Ctr & Res Inst Dept Malignant Hematol Tampa FL USACalvary Mater Hosp Dept Haematol Newcastle NSW AustraliaKing Huss

Activation of Cgas-Sting Pathway By Hypomethylating Agent in TP53 Mutated MDS/AML

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Ka Lam Nelson Ng Lam Ng Stephen Lam Xingliang Liu Koon C. Chan Lichuan Zheng Chunxiao Zhang Rachel L. S. Tse Wing Lam Natalie Nok-Man Chan Cheuk Him Man Arthur K.L. Cheung Ho-Wan Ip Chun H. Au Edmond Ma Chi T. Ng Ying Ni Run S. Li Guang Sheng Ling Suet Yi Leung Anskar Y. H. Leung

Centre for Oncology and Immunology Hong Kong Science Park Hong Kong ChinaDepartment of Medicine School of Clinical Medicine LKS Faculty of Medicine The University of Hong Kong Hong Kong ChinaDepartment of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong ChinaSchool of Biomedical Sciences LKS Faculty of Medicine The University of Hong Kong Hong Kong Hong KongDepartment of Medicine School of Clinical Medicine LKS Faculty of Medicine The University of Hong Kong Hong Kong Hong KongCentre for Oncology and Immunology Hong Kong Hong KongDepartment of Medicine School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong ChinaDepartment of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong KongCentre for PanorOmic Sciences The University of Hong Kong Hong Kong Hong KongDepartment of Pathology Queen Mary Hospital Hong Kong ChinaHong Kong Genome Institute Hong Kong Hong KongDepartment of Pathology The Hong Kong Sanatorium and Hospital Hong Kong Hong KongClinical Trials Centre The University of Hong Kong Hong Kong Hong KongDepartment of Infectious Diseases and Public Health City University of Hong Kong Hong Kong Hong KongThe Jockey Club Centre for Clinical Innovation and Discovery LKS Faculty of Medicine The University of Hong Kong Hong Kong Hong KongThe Jockey Club Centre for Clinical Innovation and Discovery Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

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Resar, Linda Kim, Joseph Supreme, Audrey-Ann Woo, Hyunsung West, Bailey Antopia, Mariah C. Thompson, Zanshe Reddy, Karen Kim, Jung-Hyun Cope, Leslie Rampal, Raajit Koche, Richard Moliterno, Alison R. Spivak, Jerry L.

Johns Hopkins Univ Sch Med Dept Med Div Hematol Baltimore MD USAJohns Hopkins Univ Dept Oncol Div Hematol Sch Med Baltimore MD USAJohns Hopkins Univ Dept Pathol Div Hematol Sch Med Baltimore MD USAJohns Hopkins Univ Sch Med Baltimore MD USAJohns Hopkins Univ Sch Med Cellular & Mol Med Grad Program Baltimore MD USAJohns Hopkins Univ Sch Med Doctoral Divers Program Baltimore MD USAJohns Hopkins Univ Whiting Sch Engn Baltimore MD USAJohns Hopkins Univ Sch Med Pathobiol Grad Program Baltimore MD USAJohns Hopkins Univ Sch Med Inst Basic Biomed Sci Baltimore MD USAJohns Hopkins Univ Sch Med Div Hematol Owings Mills MD USAJohns Hopkins Univ Sch Med New York NY USAMem Sloan Kettering Canc Ctr New York NY USAMem Sloan Kettering Canc Ctr Ctr Epigenet Res New York NY USAMem Sloan Kettering Canc Ctr Dept Med Ctr Epigenet Res Leukemia ServCtr Epigenet New York NY USAJohns Hopkins Univ Sch Med Dept Med Baltimore MD 21205 USAJohns Hopkins Univ Sch Med Dept Oncol Baltimore MD USA

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Activation of Autophagy Via the SQSTM1-KEAP1-NRF2 Axis Induced By Pevonedistat Provides a Temporary Readjustment of MDS/AML Cells Leading to the Development of Resistance

Pimkova, Kristyna Mysakova, Michaela Kokavec, Juraj Minarik, Lubomir Cermak, Lukas Stopka, Tomas

Charles Univ Prague Fac Med 1 BIOCEV Vestec Czech RepublicCzech Acad Sci Inst Mol Genet Prague Czech Republic

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Improved Hematologic Recovery with Ivosidenib in Patients with mIDH1 Relapsed or Refractory MDS: Results from a Phase 1 Substudy

Prince, Gabrielle T. Baratam, Praneeth Garcia-Manero, Guillermo Angiolillo, Anne Bhagnani, Tarun Vestin, Assaf Fathi, Amir T.

Johns Hopkins Univ Sch Med Sidney Kimmel Comprehens Canc Ctr Baltimore MD USAMed Univ South Carolina Hollings Canc Ctr Charleston SC USAUniv Texas MD Anderson Canc Ctr Dept Leukemia Houston TX USAServier Pharmaceut Boston MA USAMassachusetts Gen Hosp Canc Ctr Ctr Leukemia Boston MA USA

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The Splicing Factor RBM17 Affect the Development of MDS through Metabolic Regulation

Wang, Zhihong Lai, Yiting Wei, Hong Ding, Lingling Long, Zaifei Zhang, Wenhui Zou, Mengqi A.Andoh, Sheikh Wang, Zengbin

Fujian Prov Hosp Dept Hematol Fuzhou Peoples R ChinaFujian Med Univ Shengli Clin Med Coll Fuzhou Peoples R China

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Intraindividual Comparison of Recognition of Symptom Burden in MPN between Patient- and Physician-Reported Assessment and Its Impact on Survival- an Analysis By the German Study Group for MPN (GSG-MPN)

Manz, Kirsi Heidel, Florian H. Koschmieder, Steffen Schlag, Rudolf Lipke, Joerg Stegelmann, Frank Griesshammer, Martin Klausmann, Martine Crodel, Carl Hochhaus, Andreas Schulz, Holger Goethert, Joachim R. Al-Ali, Haifa Kathrin Becker, Heiko Reiter, Andreas Beutel, Gernot Kricheldorf, Kim Brummendorf, Tim H. H. Hoffmann, Wolfgang Doehner, Konstanze Isfort, Susanne

Univ Med Greifswald Inst Community Med Greifswald GermanyHannover Med Sch MHH Dept Hematol Hemostasis Oncol & Stem Cell Transpla Hannover GermanyHannover Med Sch Dept Hematol Hemostasis Oncol & Stem Cell Transplantat Hannover GermanyAachen Bonn Cologne Duesseldorf CIO ABCD Ctr Integrated Oncol Aachen GermanyUniv Hosp RWTH Aachen Fac Med Dept Hematol Oncol Hemostaseol & Stem Cell Transpl Aachen GermanyPractice Hematol & Oncol Wuerzburg Wurzburg GermanyPractice Hematol & Oncol Cologne GermanyUniv Hosp Ulm Dept Internal Med 3 Ulm GermanyUniv Bochum Univ Clin Hematol Oncol Hemostaseol & Palliat Care Johannes Wesling Med Ctr Minden Bochum GermanyGemeinschaftspraxis Aschaffenburg Aschaffenburg GermanyJena Univ Hosp Comprehens Canc Ctr Cent Germany Campus Jena Dept Hematol & Oncol Jena GermanyKlin Innere Med II Comprehens Canc Ctr Cent Germany Campus Jena Campus Jena D-07747 Jena GermanyOncol Practice Frechen GermanyUniv Hosp Essen West German Canc Ctr WTZ Dept Hematol & Stem Cell Transplantat Essen GermanyUniv Med Halle Krukenberg Canc Ctr Halle Halle GermanyUniv Freiburg Fac Med Dept Hematol Oncol & Stem Cell Transplantat Freiburg GermanyUniv Med Ctr Mannheim Dept Hematol & Oncol Mannheim GermanyUniv Hosp RWTH Aachen Fac Med Dept Hematol Oncol Hemostaseol & Stem Cell Transpl Aachen GermanyUniv Hosp Ulm Dept Internal Med 3 Ulm Germany