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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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关键词： 骨质疏松骨密度炎症细胞因子孟德尔随机化因果关系

Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei

Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChinaEye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChinaBranch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChinaAcademy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

An integrated metabolomics and proteomics analysis reveals copper-zinc - zinc alloy surface contact-mediated metabolic disruption, lipid peroxidation, and osmotic imbalance of Cryptocaryon irritans tomonts

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关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

Siddique, Qaisra Xie, Xiao Yin, Fei

Ningbo Univ Sch Marine Sci Natl Demonstrat Ctr Expt Aquaculture Educ 169 South Qixing Rd Ningbo 315832 Peoples R China

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关键词： Cryptocaryon irritans Tomont Copper-zinc alloy Proteomics Metabolomics Metabolic disruption Lipid peroxidation OXIDATIVE STRESS IMMUNE-RESPONSES SKIN MUCUS ACID CYCLE ACIDIFICATION DEGRADATION EXPRESSION APOPTOSIS PROTEINS

山姜素调节cAMP/PKA/CREB信号通路促进骨质疏松性骨折大鼠骨折愈合

陆飞周静金涛

连云港市第一人民医院康复医学科江苏省连云港市222000南京医科大学康达学院康复医学部江苏省连云港市222000中国人民解放军东部战区总医院健康医学科江苏省南京市210018

主要组织相容性复合体调控帕金森病的免疫反应

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关键词： 山姜素环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白骨质疏松骨折愈合大鼠

关梦雅任彬彬王晶莹

河南中医药大学康复医学院河南省郑州市450046河南中医药大学第一附属医院河南省郑州市450000

Identifying key components from Melastoma dodecandrum in TNF-α-induced osteoblast injury model through a combination of cell membrane chromatography and mass spectrometry

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关键词： 帕金森病主要组织相容性复合体先天性免疫适应性免疫小胶质细胞 T细胞 B细胞 α-突触核蛋白炎症

Mao, Jiale Lei, Houxing Xu, Pingcui Liu, Shuang Zhou, Jiwang Mei, Mingrong Wang, Nani Zhang, Xiaoqin

Zhejiang Chinese Med Univ Lishui TCM Hosp Lishui Hosp Tradit Chinese Med Lishui 323000 Peoples R ChinaZhejiang Chinese Med Univ Sch Pharmaceut Sci Hangzhou 310053 Peoples R ChinaZhejiang Prov Key Lab She Med Inheritance Innovat Lishui Peoples R ChinaLishui She Med Inheritance Innovat Dev & Applicat Lishui Peoples R ChinaZhejiang Acad Tradit Chinese Med Dept Tradit Chinese Med Hangzhou 310005 Peoples R ChinaZhejiang Prov Ethn Hosp Jingning 323500 Peoples R China

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关键词： Melastoma dodecandrum Isovitexin TNF-alpha Cell membrane chromatography Key component BONE ACTIVATION

Ultrahigh sensitivity fiber laser integrated biosensor for TNF-α detection in human blood sample

Haoyuan Cao Jiandong Liu Dandan Wei Bin Liu Yingying Hu Juan Liu Shengpeng Wan Tao Wu Xing-Dao He Jun Jiang Hengyi Xu Gerald Farrell Qiang Wu

Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong University Nanchang 330063 ChinaDepartment of Clinical Laboratory Medical Center of Burn plastic and wound repair The First Affiliated Hospital of Nanchang University ChinaJiangsu Key Laboratory of New Energy Generation and Power Conversion Nanjing University of Aeronautics and Astronautics Nanjing 211106 ChinaState Key Laboratory of Food Science and Resources Nanchang University Nanchang 330047 ChinaPhotonics Research Centre School of Electrical and Electronic Engineering City Campus Technological University Dublin Dublin 7 IrelandFaculty of Engineering and Environment Northumbria University Newcastle Upon Tyne NE1 8ST United Kingdom

运动疗法通过机械-化学偶联治疗慢性非特异性下背痛

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关键词： Biosensor TNF-α Optical fiber sensor interferometer Fiber lasers

张佳乐王富森邱镇锐樊鑫铭邹吉龙毕郑刚孙佳冰

哈尔滨医科大学附属第一医院骨科黑龙江省哈尔滨市150001

Melastoma dodecandrum lour. Protects against cerebral ischemia-reperfusion - reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress

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关键词： 机械-化学偶联运动疗法慢性非特异性下背痛腰椎稳定椎旁肌

Liu, Shuang Zhang, Xiaoqin Lin, Bingfeng Mao, Jiale Zhan, Jianhu Li, Yanyan Zhou, Jiwang Wang, Nani Qiu, Weiwen

Lishui Hosp Tradit Chinese Med Dept Pharm Lishui 323000 Zhejiang Peoples R ChinaZhejiang Acad Tradit Chinese Med Hangzhou 310007 Zhejiang Peoples R ChinaZhejiang Acad Tradit Chinese Med Dept Med Hangzhou 310007 Zhejiang Peoples R ChinaWenzhou Med Univ Wenzhou 325000 Zhejiang Peoples R China

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关键词： Melastoma dodecandrum Lour Cerebral ischemia-reperfusion Middle cerebral artery occlusion Hypoxic-glucose deprivation reperfusion Apoptosis Oxidative stress Endoplasmic reticulum stress

Synthesis of novel imidazole-based compounds via using sonication technique: Influence of chemical reaction manipulation, antiproliferative activity through apoptosis induction, cell migration inhibition, and antioxidant properties

El-Mawgoud, Heba K. Abd Aboulmagd, Asmaa M. Hemdan, Magdy M. Farag, Paula S. Hassaballah, Aya I.

Ain Shams Univ Fac Women Arts Sci & Educ Chem Dept Cairo EgyptNahda Univ NUB Fac Pharm Pharmaceut Chem Dept Bani Suwayf EgyptAin Shams Univ Fac Sci Chem Dept Cairo 11566 Egypt