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Specific Clinical Features Define HLA-A*32:01 Positive Vancomycin Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) A Multi-institution Cross-sectional Study

Matthew S Krantz Chantal Lemoine Li Zhou Andrew J King Daniela Kroshinsky Elizabeth J Phillips Kimberly G Blumenthal

Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USADepartment of Biomedical Informatics Vanderbilt University Medical Center Nashville Tennessee USACenter for Drug Safety and Immunology Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA.Division of Rheumatology Allergy and Immunology Department of Medicine Massachusetts General Hospital Boston MA USAHarvard Medical School Boston MA.Harvard Medical School Boston MADivision of General Internal Medicine Brigham and Women's Hospital Boston MA.Department of Dermatology Duke University School of Medicine Durham NC.Center for Drug Safety and Immunology Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USADivision of Infectious Diseases Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USADepartment of Pharmacology Vanderbilt University School of Medicine Nashville Tennessee USA.Department of Dermatology Massachusetts General Hospital Boston MA. Electronic address: kblumenthal@mgh.harvard.edu.

来源 PubMed期刊

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关键词： Acute kidney injury Drug causality Drug reaction with eosinophilia and systemic symptoms Human leukocyte antigens Latency RegiSCAR Severe cutaneous adverse drug reactions Vancomycin

Coexistence of IgG4-Related Disease and Renal Anastomosing Hemangioma: A Rare Diagnostic Challenge

Yo Mizuta Shunichi Fujita Masatomo Yamada Masakatsu Ikeda Yuka Koide Sumie Hiramatsu-Asano Kazuhiro Komi Hirotake Nishimura Yoshitaka Morita Kazuhisa Nakano

Departments of Rheumatology Kawasaki Medical School Japan.Departments of Pathology Kawasaki Medical School Japan.

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Glycans and Chirality: Stereoselectivity at the Core of DC-SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

Martinez, J. Daniel Nunez-Franco, Reyes Valverde, Pablo Delgado, Sandra Arda, Ana Jimenez-Barbero, Jesus Jimenez-Oses, Gonzalo Canada, F. Javier

CSIC Ctr Invest Biol Margarita Salas Ramiro Maeztu 9 Madrid 28040 SpainBasque Res Technol Alliance BRTA C bioGUNE Bizkaia Technol Pk Bldg 800 Derio 48160 SpainBasque Fdn Sci Ikerbasque Bilbao 48013 SpainTechnol Univ Basque Country EHU UPV Fac Sci Dept Organ Chem 2 Leioa SpainCIBER Enfermedades Resp CIBERES Avda Monforte Lemos 3-5 Madrid 28029 Spain

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关键词： chiral recognition glycans lectins molecular recognition NMR

LncRNA MIR155HG suppresses cell apoptosis by activating autophagy via miR-7036b-3p/GPNMB axis and AMPK/mTOR signaling in spinal cord injury

Ruoxi Liu Jintao Ye Sihua Huang

Department of Orthopaedic Surgery Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Xi'an 710004 China

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关键词： Spinal cord injury MIR155HG GPNMB AMPK/mTOR apoptosis autophagy AMPK 5'AMP-activated protein kinase ANOVA analysis of variance ANXA2 annexin A2 ATG101 autophagy-related protein 101 ATG13 autophagy-related protein 13 Bax Bcl-2 associated X-protein BBB Basso-Beattie-Bresnahan Bcl-2 B-cell lymphoma 2 BRD4 bromodomain-containing protein 4 CTSB cathepsin B CTSD cathepsin D CTSL cathepsin L cDNA complementary DNA ceRNA competing endogenous RNA Cyt-c Cytochrome c DAPI 4',6-Diamidino-2'-phenylindole EDTA ethylenediaminetetraacetic acid FBS fetal bovine serum FIP200 FAK family kinase-interacting protein of 200 kDa GAPDH glyceraldehyde-3-phosphate dehydrogenase Glu glutamate GPNMB glycoprotein nonmetastatic melanoma protein B HE hematoxylin and eosin HO heme oxygenase H 2 O 2 hydrogen peroxide LAMP1 lysosomal-associated membrane protein 1 LAMP2 lysosomal-associated membrane protein 2 LC3 light chain 3 lncRNAs long non-coding RNAs MALAT1 metastasis-associated lung adenocarcinoma transcript-1 MAPK mitogen-activated protein kinase MEF2A myocyte enhancer factor 2A MIR155HG microRNA 155 host gene mTOR mammalian target of rapamycin mTORC1/2 mTOR complex 1/2 Mut mutant NC negative control PBS phosphate-buffered saline PI propidium iodide PIKK PI3K-related kinase PI3K phosphatidylinositol 3-kinase PVDF polyvinylidene fluoride RIPA radio-immunoprecipitation assay RT room temperature RT-qPCR reverse transcription-quantitative polymerase chain reaction SCI spinal cord injury SD standard deviation SDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresis shRNA short hairpin RNA TBST Tris-buffered saline with Tween-20 TFEB transcription factor EB TUNEL terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay ULK1 UNC-51 like kinase 1 WIPI2 WD-repeat domain phosphoinositide-interacting protein 2 Wt wild type 3-MA 3-methyladenine

Safety and efficacy profile of anti-IL17 treatments in hidradenitis suppurativa: systematic review and meta-analysis of randomized placebo-controlled trials

O Al-Wattar-Ceballos L Martínez-Montalvo M Carmona-Rodríguez

Dermatology Department Hospital General Universitario de Ciudad Real Ciudad Real Spain. Electronic address: oalwattar@sescam.jccm.es.Dermatology Department Hospital General Universitario de Ciudad Real Ciudad Real Spain.

来源 PubMed期刊

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关键词： Adultos, Tratamiento Adults Hidradenitis Supurativa Interleucina-17 Interleukin 17 Meta-Analysis Metaanálisis Suppurative Hidradenitis Treatment

P53-Induced Autophagy Degradation of NKX3-2 Improves Ovarian Cancer Prognosis

Alessandra Ferraresi Ian Ghezzi Amreen Salwa Chiara Lualdi Danny N. Dhanasekaran Ciro Isidoro

Laboratory of Molecular Pathology Department of Health Sciences Università del Piemonte Orientale Via Solaroli 17 28100 Novara ItalyStephenson Cancer Center The University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

来源 PubMed期刊 MultidisciplinaryDig...

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关键词： BAPX1 p53 autophagy lysosome apoptosis cancer cell metabolism TCGA prognosis personalized medicine ovarian cancer

Targeting intracellular LMP2 with costimulatory signal-armed antibody-like TCR T cells

Jiali Cheng Xuelian Hu Zhenyu Dai Yuhao Zeng Jin Jin Wei Mu Qiaoe Wei Xiangyin Jia Jianwei Liu Meng Xie Qian Luo Guang Hu Gaoxiang Wang Xiaojian Zhu Jianfeng Zhou Min Xiao Jue Wang Taochao Tan Liang Huang

Department of Hematology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan China.Immunotherapy Research Center for Hematologic Diseases of Hubei Province Wuhan China.Department of Hematology The First Affiliated Hospital of Zhejiang University Zhejiang University Hangzhou China.Department of Internal Medicine Cleveland Clinic Akron General Cleveland Ohio USA.Division of General Internal Medicine Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.IASO Biotherapeutics Nanjing China.State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.Tianjin Institutes of Health Science Tianjin China.

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关键词： Cancer immunotherapy Immunotherapy Infectious disease Therapeutics

Assessment of the anticancer function of Coronilla orientalis MILLER through comprehensive in vitro and computational studies

Ciftci, Halilibrahim Oral, Ayhan Coskun, Yalcin Renda, Gulin Otsuka, Masami Fujita, Mikako Sever, Belgin

Burdur Mehmet Akif Ersoy Univ Dept Mol Biol & Genet Istiklal Campus Burdur TurkiyeIzmir Katip Celebi Univ Dept Bioengn Sci Izmir TurkiyeKumamoto Univ Fac Life Sci Med & Biol Chem Sci Farm Joint Res Lab Kumamoto 8620973 JapanSci Farm Ltd Dept Drug Discovery Kumamoto JapanCanakkale Onsekiz Mart Univ Fac Sci Dept Chem Canakkale TurkiyeCanakkale Onsekiz Mart Univ Lapseki Vocat Coll Dept Plant Prod & Anim Husb Canakkale TurkiyeKaradeniz Tech Univ Fac Pharm Dept Pharmacognosy Trabzon TurkiyeAnadolu Univ Fac Pharm Dept Pharmaceut Chem TR-26470 Eskisehir Turkiye

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关键词： NSCLC breast cancer natural product apoptosis EGFR HER-2

Impaired IgA Mucosal Immunity Following Lung Transplantation: A Potential Trigger for Bronchiolitis Obliterans Syndrome

François M Carlier Bruno Detry Jérôme Ambroise Nicolas Heddebaut Thomas Planté-Bordeneuve Aurélie Daumerie Elisabeth Longchampt Loïc Falque Martine Reynaud-Gaubert Sandrine Hirschi Jean-François Mornex Xavier Demant Adrien Tissot Jérôme Le Pavec Vincent Bunel David Lair Marina Pretolani Alexandre Vallée Charles Pilette Olivier Brugière

Pôle Pneumologie ORL et Dermatologie (LUNS) Institut de Recherche expérimentale et clinique (IREC) UCLouvain Bruxelles Belgique francois.carlier@chuuclnamur.uclouvain.be.Centre de Transplantation Pulmonaire CHU UCL Namur Yvoir Belgique.Service de Pneumologie CHU UCL Namur Yvoir Belgique.Unité de Recherche INSERM U1152 Université Paris-Descartes Paris France.Pôle Pneumologie ORL et Dermatologie (LUNS) Institut de Recherche expérimentale et clinique (IREC) UCLouvain Bruxelles Belgique.Centre de Technologies moléculaires appliquées (CTMA) Institut de Recherche expérimentale et clinique (IREC) UCLouvain Bruxelles Belgique.IREC Imaging Platform (2IP) Institut de Recherche expérimentale et clinique UCLouvain Bruxelles Belgique.Service d'anatomie pathologique Hôpital Foch Suresnes France.Service de Pneumologie et Transplantation Pulmonaire CHU de Grenoble Grenoble France.Service de Pneumologie et Transplantation Pulmonaire CHU de Marseille APHM Hôpital NordAix Marseille Université Marseille France.Service de Pneumologie et Transplantation Pulmonaire Hôpitaux universitaires de Strasbourg Strasbourg France.Hospices Civils de Lyon CIC1407 INSERM UMR754 IVPC Université Claude Bernard Lyon 1 INRAE EPHE Lyon France.Service de Pneumologie et Transplantation Pulmonaire CHU de Bordeaux Bordeaux France.Nantes Université CHU Nantes INSERM Service de Pneumologie L'Institut du Thorax Center for Research in Transplantation and Translational Immunology UMR 1064 Nantes France.Service de Pneumologie et Transplantation Pulmonaire Centre Chirurgical Marie-Lannelongue Le Plessis-Robinson Franc.Service de Pneumologie B et Transplantation Pulmonaire Hôpital Bichat (AP-HP) Paris France.Département de biostatistiques - DRCI Hôpital Foch Suresnes France.Service de Pneumologie Cliniques Universitaires Saint-Luc Bruxelles Belgique.Service de Transplantation Pulmonaire et Centre de compétence de la Mucoviscidose Hôpital Foch Suresnes France.

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IL-6 as a Mediator of Platelet Hyper-Responsiveness

Connor Elliot Webb Jordan Vautrinot Ingeborg Hers

School of Physiology Pharmacology and Neuroscience Biomedical Sciences Building University Walk Bristol BS8 1TD UK

来源 PubMed期刊 MultidisciplinaryDig...

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关键词： interleukin-6 platelets hyper-responsiveness thrombo-inflammation thrombosis

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